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Martin L. Yarmush, M.D., Ph.D.

AIMBE College of Fellows Class of 1993
For the development of novel immunologic tools and for establishing long-term stable culture systems for use in artificial liver devices.

Coming a step closer to understanding how gastric bypass works

Via Medical Xpress | October 5, 2017

A study by a team of researchers at the Massachusetts General Hospital Center for Engineering in Medicine (MGH-CEM) and Shriners Hospital for Children has made a technological advancement toward accelerating the discovery of drug targets for obesity, type II diabetes and other metabolic diseases. The novel experimental and computational workflow involves the first use of rodent gastric bypass models, state-of-the-art mass spectrometry and an array of bioinformatics tools to begin unraveling how gastric bypass surgery leads to weight loss and a resolution of type 2 diabetes. Their report on the impact of the surgery on liver metabolism appeared last month in the journal Technology.

Martin Yarmush, MD, PhD, director of the MGH-CEM and co-corresponding author of the paper, stresses the multi-disciplinary nature of the work. “Investigators in the field have long sought after this type of multi-omic analysis on a rodent gastric bypass model to study metabolic disease, but the work required expertise in rodent surgery, multi-omic analytics, and computational biology. At the CEM, we enable engineering scientists to tackle complex problems in biomedicine at a world-class research hospital in collaboration with clinicians. This work will likely be of great interest to biotechnology companies aspiring to build their drug pipeline in the metabolic disease area… Continue reading.

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‘Lab-on-a-Chip’ Could Cut Costs of Sophisticated Diagnostic Tests

Via MDT | September 14, 2015

Rutgers engineers have developed a breakthrough device that can significantly reduce the cost of sophisticated lab tests for medical disorders and diseases, such as HIV, Lyme disease and syphilis.

The new device uses miniaturized channels and valves to replace “benchtop” assays – tests that require large samples of blood or other fluids and expensive chemicals that lab technicians manually mix in trays of tubes or plastic plates with cup-like depressions….

“The results are as sensitive and accurate as the standard benchtop assay,” said Martin Yarmush, the Paul and Mary Monroe Chair and Distinguished Professor of biomedical engineering at Rutgers and Ghodbane’s adviser.

Until now, animal research on central nervous system disorders, such as spinal cord injury and Parkinson’s disease, has been limited because researchers could not extract sufficient cerebrospinal fluid to perform conventional assays.

“With our technology, researchers will be able to perform large-scale controlled studies with comparable accuracy to conventional assays,” Yarmush said.

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