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Laura Marcu, Ph.D.

AIMBE College of Fellows Class of 2011
For development of optical instrumentation for tissue spectroscopy and imaging and its application to cancer and atherosclerosis.

Novel catheter combines FLIm, IVUS to assess plaque buildup in heart patients

Via Health Imaging | October 11, 2017

A newly developed, single-catheter probe that combines intravascular ultrasounds with fluorescence lifetime imaging (FLIm) in one device could be the answer to physicians’ difficulties predicting plaque rupture, a study published in Scientific Reports suggests.

The catheter was developed by Laura Marcu, PhD, and colleagues at her UC Davis-based lab. The device was a response to the fact that plaque rupture—an often fatal event that spurs heart attacks—is the number one root problem leading to sudden cardiac deaths in the U.S.

Previous attempts to identify plaque buildup in arteries have been limited; many cardiologists order angiographies, but those screenings only identify stenosis in blood vessels, and not all plaque buildup results in the narrowing of arteries. Intravascular ultrasounds (IVUS) can identify plaque burden based on its penetration depth of up to 10 mm-squared, Marcu and co-authors explained, but don’t have the spatial ability to recognize smaller-scale, biochemical changes in vessels. Optical coherence tomography succeeds in spatial resolution, but lacks the penetration depth necessary to assess plaque buildup… Continue reading.

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Laura Marcu Named a Fellow of the Optical Society

Via UC Davis Bioengineering | January 17, 2014

Laura Marcu, a professor in the UC Davis Department of Biomedical Engineering, has been named a Fellow of the Optical Society (OSA). The nomination and selection process is highly competitive: OSA Fellows are chosen based on their overall impact on optics, as gauged via factors such as specific scientific, engineering and technological contributions; a record of significant publications or patents related to optics; technical leadership in the field; and serve to OSA and the global optics community.

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