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Elazer R. Edelman, M.D., Ph.D., F.A.C.C.

AIMBE College of Fellows Class of 2001
For embodying the melding of science and medicine, engineering and biology; leveraging technical innovation with rigorous thought to unravel mechanisms of disease.

Metastasis Study Illuminates How Cancer Will ‘Hijack’ Healthy Cells

Via Harvard | December 16, 2015

Metastasis — the spread of cancer from one part of the body to others — accounts for more than 90 percent of cancer-related deaths. Although the cells that seed metastasis and the sites they tend to travel to have been increasingly studied over the years, little has been known about how cancer migrates from a primary site, such as breast tissue, to a secondary site, such as the brain or bone marrow.

A study by researchers from Harvard-affiliated Brigham and Women’s Hospital (BWH), published in Nature Communications, offers a new view of how cancer cells extend their reach, co-opting and transforming normal cells through “metastatic hijacking.” The researchers also find that in preclinical models, pharmacological intervention can stop the hijack before it starts, pointing to new therapeutic targets for preventing cancer cells from spreading.

“Metastasis remains a final frontier in the search for a cure for cancer,” said Shiladitya Sengupta of BWH’s Bioengineering Division in the Department of Medicine and corresponding author of the study. “For the past five years we have studied how cancer travels to other parts of the body, and what we find is that communication is key.”

“By working together, our labs have been able to gain greater insights into cell-cell communication in tumor states, which will shed new light on cancer as a disease and the promise and potential of emerging innovative therapies,” said Elazer Edelman of BWH’s Cardiovascular Division in the Department of Medicine.

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Health Sciences, Technology Expert Edelman Set for Discovery Lecture

Via Vanderbilt | October 29, 2015

Elazer Edelman, M.D., Ph.D., a pioneer in the application of engineering and physical sciences to understand fundamental biological processes and the mechanisms of disease, will deliver the next Flexner Discovery Lecture on Thursday, Nov. 5.

Edelman is the Thomas D. and Virginia W. Cabot Professor of Health Sciences and Technology at the Massachusetts Institute of Technology (MIT), professor of Medicine at Harvard Medical School, director of the Harvard-MIT Biomedical Engineering Center and a member of the Institute of Medicine and National Academy of Engineering.

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