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William Federspiel, Ph.D.

AIMBE College of Fellows Class of 1999
For outstanding contribution toward the development of implantable artificial lungs and quantifying oxygen exchange in living and artificial systems.

ALung Technologies Recipient of Gold Award at Medical Design Excellence Awards

Via Medical Device and Diagnostic Industry | June 12, 2014

Pittsburgh, PA (June 12, 2014) – ALung Technologies, Inc., the leading provider of low-flow extracorporeal carbon dioxide removal (ECCO2R) technologies for treating patients with acute respiratory failure, announced today that the Hemolung Respiratory Assist System (RAS) has won the Gold Award in the Critical-Care and Emergency Medicine Category of the 17th Annual Medical Design Excellence Awards (MDEA) competition. Winners were announced yesterday at a ceremony in conjunction with the MD&M East conference in New York.

The Hemolung RAS provides Respiratory Dialysis®, a simple, minimally invasive form of extracorporeal carbon dioxide removal which serves as an alternative or supplement to mechanical ventilation for critically ill patients suffering from acute respiratory failure due to conditions like acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). Unlike mechanical ventilation, the Hemolung RAS is minimally invasive and works by removing carbon dioxide and delivering oxygen
directly to the blood, allowing the lungs to rest and heal. The device is currently approved for use in 29 countries across Europe, the Middle East and Asia-Pacific.

Development of the Hemolung RAS began over 10 years ago in the laboratory of Dr. William Federspiel, W.K. Whiteford Professor of Bioengineering, Chemical Engineering, and Critical Care Medicine at the University of Pittsburgh and co-founder of ALung Technologies. “The Hemolung RAS is a perfect example of how a strong collaboration between academic and industrial partners can effectively bring life-changing medical technologies from ‘bench-to-bedside’,” added Mr. DeComo. “We continue to support efforts at the University of Pittsburgh to develop a variety of next generation extracorporeal technologies, and we are very excited by some of the advancements they are making.”

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Wearable Artificial Lung to Be Developed at Pitt Through $3.4 Million Grant

Via University of Pittsburgh News | March 19, 2013

Each year, nearly 350,000 Americans die of some form of lung disease, with another 150,000 patients needing short- and long-term care. Unfortunately, current breathing-support technologies are cumbersome, often requiring patients to be bedridden and sedated.

Now, with the support of a $3.4 million National Institutes of Health grant, researchers at the University of Pittsburgh will develop an artificial lung to serve as a bridge to transplant or recovery in patients with acute and chronic lung failure.

“Our wearable lung will be designed to get patients up and moving within the hospital setting, which is important for both patient recovery and improving a patient’s status prior to a lung transplant,” said principal investigator William J. Federspiel, William Kepler Whiteford Professor of Bioengineering in Pitt’s Swanson School of Engineering and director of the Medical Devices Laboratory within the Pitt-UPMC McGowan Institute for Regenerative Medicine.

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ALung Technologies Presents Positive Clinical Trial Results of the Hemolung Respiratory Assist System

Via ALung | June 18, 2012

ALung Technologies, Inc., a leading developer of innovative lung assist devices, presented an analysis of its recent clinical trial of the Hemolung Respiratory Assist System (RAS) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). The data were presented during the session “Chronic and Acute Hypercapnic Failure – Management with low flow CO2 devices” on Friday, June 15th at the 58th Annual Conference of the American Society of Artificial Internal Organs (ASAIO) in San Francisco.

The presentation, entitled “Extracorporeal CO2 Removal (ECCO2R) for Preventing Intubation in Patients with Exacerbated COPD: Results of the Hemolung Pilot Study,” by Dr. William Federspiel, Professor of Bioengineering at the University of Pittsburgh and Chairman of ALung’s Scientific Advisory Board, provided data from a subset of seven patients with acute exacerbation of COPD who were failing non-invasive ventilation (NIV) and at a high risk of being intubated and placed on invasive mechanical ventilation (IMV). Patients in the study were provided ECCO2R with the Hemolung RAS to remove retained carbon dioxide. The study was led by principal investigator Prof. Dr. Felix Herth of the Thoraxklinik and University Hospital, Heidelberg, Germany.

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