Klaus F. Ley, M.D.

AIMBE College of Fellows Class of 2001
For outstanding contributions to the understanding of the mechanics of adhesion molecules and their role in inflammation and atherosclerosis.

How T-cells navigate the rough-and-tumble environment of the bloodstream

Via Science Daily | December 26, 2017

To eradicate pathogens or counteract inflammation, cells of the immune system move through often rapid blood flow toward peripheral disease sites, such as skin, gut or lung. Thus a goal of immunologists has been to define the repertoire of molecules that not only keep fast-moving immune cells on course but allow them to access inflamed tissues.

Now, a team led by La Jolla Institute for Allergy and Immunology (LJI) researcher Klaus Ley, M.D., reports that helper T cells move toward inflamed tissue using membrane protrusions that stabilize them and provide traction on the vasculature. Using high-resolution microscopy and global molecular analysis, the team shows that immature T cells lack these protrusions but that maturing T-cells switch on a gene expression program to create material to construct them… Continue reading.