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Paula Hammond, Ph.D.

AIMBE College of Fellows Class of 2010
For outstanding contributions to the design of novel biomaterials and carriers for drug delivery.

Advancing Medicine, Layer by Layer

Via Phys Org | July 2, 2014

Personalized cancer treatments and better bone implants could grow from techniques demonstrated by graduate students Stephen W. Morton and Nisarg J. Shah, who are both working in chemical engineering professor Paula Hammond’s lab at MIT.

Morton’s work focuses on developing drug-carrying nanoparticles to target hard-to-treat cancers—such as triple-negative breast cancer (TNBC)—while Shah develops coatings that promote better adhesion for bone implants.

Their work shares a materials-based approach that uses layer-by-layer assembly of nanoparticles and coatings. This approach provides controlled release of desirable components from chemotherapy drugs to bone growth factors. Use of natural materials promises to reduce harmful side effects.

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Nanoparticles Attack Aggressive Tumors

Via MIT Library News | October 31, 2013

MIT chemical engineers have developed a new treatment for an aggressive form of breast cancer whose tumors resist chemotherapy drugs. Led by David H. Koch Professor in Engineering Paula Hammond, the team designed nanoparticles that pack a one-two punch: They deliver a cancer drug along with short strands of RNA that shut off genes used by cancer cells to escape the drug. The nanoparticles are also coated with an outer layer that protects them from degrading while en route to the cancer cells. The researchers used the particles to successfully shrink breast tumors in mice, as they report in a recent issue of the journal ACS Nano. The lead author on the paper is Jason Deng, a postdoc in Hammond’s lab.

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