Encellin, a San Francisco–based biotechnology company, has obtained exclusive worldwide rights from UC San Francisco for a proprietary cell encapsulation technology aimed at improving physicians’ ability to perform cell transplants without the need for immunosuppressive drugs.
Based on ongoing preclinical trials in animal models, the technology – in the form of a pouch approximately the diameter of a quarter, made of an ultrathin nanoporous membrane – represents a significant advance towards the ability to transplant donated cells without danger of immune rejection or harmful fibrosis at the transplant site, while also ensuring that transplanted cells cannot infiltrate other parts of the body.
Encellin first aims to apply this technology – originally developed in the laboratory of Tejal Desai, PhD, chair of the Department of Bioengineering and Therapeutic Sciences in UCSF’s schools of Pharmacy and Medicine – to treat type 1 diabetes, an autoimmune disease affecting over 1 million Americans, with over 9,000 young people newly diagnosed each year.
Type 1 diabetes is caused by the loss of the islet cells of the pancreas, which normally secrete the hormone insulin to coordinate the body’s use of blood glucose. The transplantation of functional, insulin-producing pancreatic islet cells from a donor has shown clinical efficacy as a treatment for some people with type 1 diabetes, but – like most transplantation techniques – this treatment requires lifelong immunosuppression to prevent patient immune systems from destroying the donor cells. However, these immunosuppression drugs also make patients susceptible to heightened risk of infection, cancer, and organ damage… Continue reading....
Five UC San Francisco faculty members are among the 70 new members elected to the National Academy of Medicine (NAM), formerly known as the Institute of Medicine (IOM).
The 70 new regular members and 10 international members were announced at the institute’s 45th annual meeting on Monday.
The announcement recognizes individuals who have made outstanding contributions to the fields of health and medicine, and is considered one of the highest honors in these disciplines. With Monday’s announcement, a total of 97 people from UCSF are now members of the NAM.
“These five new members represent an amazing diversity of research and contributions to global health and science, and I am proud of each one of them,” said Talmadge E. King, Jr., MD, dean of the UCSF School of Medicine.
Tejal Desai conducts cutting-edge research on micro- and nano-scale technologies for targeted drug delivery. Her lab at UCSF has developed nanostructured thin-film devices to deliver drugs to the eye, silicon nanowire-coated beads as adhesive drug-delivery vehicles to the gut, and other microscopic devices. In ongoing studies, her lab is focused on ways to reduce inflammation following surgery to repair arteries or insert stents into blood vessels. Early in her career, Desai received the Visionary Science Award from the BioMEMS and Nanotechnology Society, and the Global Indus Technovator Award from MIT....
Tejal A. Desai, PhD, professor and chair of the Department of Bioengineering & Therapeutic Sciences, was awarded the 2015 Brown Engineering Alumni Medal (BEAM) from Brown University’s School of Engineering at an Awards Dinner on May 23, in recognition of her career achievements in the field of engineering. She was honored in Alumnae Hall at Brown University, in the presence of many friends, colleagues, former professors, and her husband Dr. Sanjay Saxena.
Desai is an acknowledged world leader in therapeutic microscale and nanoscale technologies and is at the forefront of engineering the next generation of drugs, using the tools of semiconductor manufacturing from Silicon Valley to make miniscule medical devices that deliver a drug or multiple drugs directly to specific areas of concern. Results from her lab include the use of silicon nanowire coated silica beads as adhesive drug-delivery vehicles, especially to the human gut, the micro/nanoscale cage or biocapsule for controlled drug delivery, and nanostructured thin-film devices for controlled ocular drug delivery.
An elected fellow of the American Institute of Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society, Desai is also a recipient of the prestigious Paul Dawson Biotechnology Award from the American Association of Colleges of Pharmacy (AACP). Early in her career, she was selected as one of the “Brilliant 10” Top Scientists in the Nation by Popular Science, received the Visionary Science Award from the BioMEMS and Nanotechnology Society, and the Global Indus Technovator Award from MIT....
Tejal Desai, PhD, has been named the new chair of the Department of Bioengineering and Therapeutic Sciences (BTS), a joint department within the UC San Francisco School of Pharmacy and School of Medicine. Her appointment is effective August 1.
“I am delighted Tejal will chair the Department of Bioengineering and Therapeutic Sciences,” said Chancellor Sam Hawgood, MBBS, who is also serving as School of Medicine Dean. “She has the vision, energy, and experience that will ensure the department continues to thrive.”
“Tejal’s willingness to serve as department chair is characteristic of her collegial approach to science and education,” added School of Pharmacy Dean B. Joseph Guglielmo, PharmD. “She is an award-winning bioengineer and an accomplished teacher and administrator who has the deep respect of the faculty. I’m very pleased Tejal has accepted the chair position.”...
Patients suffering from eye diseases such as glaucoma and macular degeneration benefit from the availability of highly effective medicines.
However, the methods for delivering these drugs to the eye keep patients trapped in a cycle of constant maintenance with monthly injections or cumbersome eye drops multiple times a day.
Robert Bhisitkul, MD, PhD, a professor of clinical opthamology at UC San Francisco, is all too familiar with this challenge and is working with Tejal Desai, PhD, professor of bioengineering and therapeutic sciences, on a solution to help improve the lives of patients.
LaunchPad, a project of UCSF’s Clinical and Translational Science Institute, is designed to highlight the experiences and accomplishments of UCSF’s translational researchers, and to support them in their efforts to develop beneficial medical products.
“It’s a problem that has had only limited progress for decades and with Tejal’s technology we see a way to completely change this field,” says Bhisitkul. Desai works on the design, fabrication and use of advanced micro/nano biosystems, and has been developing a tiny, flexible, implantable film that is able to deliver conventional medicines and also complex antibody-based drugs used in retinal disease therapies....
Innovation can be born of necessity, conscience, creativity, luck, or more likely, all of the above, all at once. Whatever the impetus, the active ingredient of invention is collaboration.
The five scientists highlighted here — bioengineers Tejal Desai and Shuvo Roy, MD/PhD candidate Mozziyar Etemadi, microbiologist Joe DeRisi, and physician/surgeon Dr. Michael Harrison — trace intersecting paths, tapping each other’s expertise nearly constantly.
When technology and need collide, Harrison sees alliances with engineers as a portal to a new realm of efficacy. “When we have a problem and there’s a missing piece, we don’t just wonder if someone will come up with it someday,” says Harrison. “We just go out and do it, together.”...
UCSF bioengineer Tejal Desai, PhD, will receive the 2012 Paul R. Dawson Biotechnology Award from the American Association of Colleges of Pharmacy (AACP) at the group’s annual meeting in July.
The award honors Desai for her contributions to contemporary teaching and scholarship in biotechnology. She is a faculty member and vice chair for education of the Department of Bioengineering and Therapeutic Sciences (BTS), a joint department of the UCSF Schools of Pharmacy and Medicine...
As a Santa Barbara high school student, UCSF bioengineer Tejal Desai got a kick out of making things work. Her father was a chemical engineer, and she thought she knew what engineering was all about.
So, she was startled when a bioengineer visited her class and told the students about research to develop artificial organs and implants.
“I was very excited,” said Desai, PhD, a professor in the Department of Bioengineering and Therapeutic Sciences in the UCSF School of Pharmacy. “I had always thought that engineering was about building bridges and mechanical devices. I didn’t know you could use it to help people.”
The class visit was part of a national program to encourage girls to pursue engineering careers. The revelation about artificial organs started Desai on two paths. She not only became a bioengineer, but also an outspoken advocate for young women entering science and engineering fields....
A pill filled with microscopic, drug-laden adhesive patches is at the center of an agreement between UCSF and Zcube srl, the research corporate venture arm of Italian pharmaceutical leader Zambon Co., SpA, to license UCSF-developed microtechnology and support early research into new ways to deliver oral medications directly to a targeted site in the body.
This is the first sponsored research agreement between Zcube and UCSF, but is expected to be one of several such agreements with the biomedical university....
Together, diabetes and end-stage renal disease (ESRD) drive billions of dollars in health care costs each year, while hampering quality of life and causing premature death in millions of people worldwide. Existing therapies, while helpful, are flawed.
Now two projects funded by the National Institutes of Health at UCSF’s Department of Bioengineering and Therapeutic Sciences – one for an insulin pump, another for a wearable, artificial kidney – promise innovative therapies for both conditions.
The projects’ principal investigators – Tejal Desai, PhD, and Shuvo Roy, PhD – believe they are about five years away from clinical trials. Equally important, the advances in biomedical micro-electro-mechanical systems (bioMEMS) and nanotechnologies their projects represent have the potential to transform medicine in the same way that semiconductors transformed electronics....