Chih-Chang Chu, Ph.D.

AIMBE College of Fellows Class of 2014
For the development of novel biomaterials with controlled rates of degradation, for wound closure, treatment of burns, and drug delivery.

Biodegradable Biomaterial Platform Technology for Human Body Repair

Via Cornell University CCTEC | March 1, 2011

Dr. Chih-Chang “C.C.” Chu, the Rebecca Q. Morgan ’60 Professor of Fiber Science at Cornell University, has developed many technologies with new biomaterials. His research includes the design and synthesis of biodegradable polymeric biomaterials for wound healing/closure, tissue regeneration, vascular grafts, heart valves, artificial skins, bone regeneration, infection control, drug control/release, DNA carriers for gene therapy, identification and forensic purposes.

Specifically, Dr. Chu and his laboratory developed an entirely new family of enzymatically biodegradable amino acid-based polymers called poly(ester amide)s (PEA) or “pseudo-proteins” exhibiting both protein and non-protein properties. PEAs elicit much lower inflammatory responses than many FDA-approved commercial biomaterials. When coupled with PEAs, commercial biomaterials also reduce their inflammation elicitation. Such ability to attenuate inflammation offers major advantages in promoting natural wound healing, reducing implant-derived complications, or improving success rates of surgical implants. As such, PEAs are ideal coatings for medical devices for either drug-elution or for improving other performance characteristics in vivo. PEAs also support proliferation of diverse cell types and therefore are useful for either tissue engineering or production of biologics.