Frederick R. Haselton, Ph.D.

AIMBE College of Fellows Class of 2007
For outstanding contributions to research and teaching in cell bioengineering, endothelial function, retinal pathophysilogy and, microarray technology.

DNA Duplicator Small Enough To Hold In Your Hand

Via Vanderbilt | January 12, 2017

Imagine a “DNA photocopier” small enough to hold in your hand that could identify the bacteria or virus causing an infection even before the symptoms appear.

This possibility is raised by a fundamentally new method for controlling a powerful but finicky process called the polymerase chain reaction. PCR was developed in 1983 by Kary Mullis, who received the Nobel Prize for his invention. It is generally considered one of the most important advances in the field of molecular biology because it can make billions of identical copies of small segments of DNA so they can be used in molecular and genetic analyses.

Vanderbilt University biomedical engineers Nicholas Adams and Frederick Haselton came up with an out-of-the-box idea, which they call adaptive PCR. It uses left-handed DNA (L-DNA) to monitor and control the molecular reactions that take place in the PCR process.