Abraham M. Lenhoff, Ph.D.

AIMBE College of Fellows Class of 2003
For application of protein biophysical methods and modeling to understanding engineering systems in chromatography, crystallization, and other separations processes.

Monoclonal Antibody HCP Challenges

Via Genetic Engineering & Biotechnology News | December 27, 2023

One longstanding and ongoing challenge for bioprocessors is the removal of host-cell proteins (HCPs).

“The entire HCP field has taken off in the last several years and numerous groups have contributed to it,” says Abraham Lenhoff, PhD, Allan P. Colburn Professor of Chemical Engineering in the department of chemical and biomolecular engineering at the University of Delaware in Newark. HCPs “have historically been assayed as a combined group,” Lenhoff explains. “The more recent attention has been on individual HCPs that can be damaging even if present in only low concentrations… Continue reading.