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Melody Swartz, Ph.D.

AIMBE College of Fellows Class of 2008
For pioneering contributions to the eludiation of novel biophysical mechanisms of morphogenesis and cell homing involving interstatial flow.

Breakthrough helps fight ‘cold’ tumors that don’t respond to immunotherapy

Via University of Chicago | April 30, 2020

Immunotherapy, which unleashes the power of the body’s own immune system to find and destroy cancer cells, has shown promise in treating several types of cancer.

But the disease is notorious for cloaking itself from the immune system, and tumors that are not inflamed and do not elicit a response from the immune system—so-called “cold” tumors—do not respond to immunotherapies.

Researchers at the Pritzker School of Molecular Engineering at the University of Chicago have taken a step toward solving this problem with an innovative immunotherapy delivery system. The system finds tumors by seeking out and binding to the tumors’ collagen, then uses a protein called IL-12 to inflame the tumor and activate the immune system, thereby activating immunotherapy… Continue reading.