David Klonoff, M.D., F.A.C.P.

AIMBE College of Fellows Class of 2013
For leadership in developing and applying diabetes technology to monitor glucose, deliver insulin, manage glycemic data, and build closed-loop systems.

GLP-1s not tied to higher risk for surgical complications for adults with diabetes

Via Healio | May 22, 2024

On June 29, 2023, the American Society of Anesthesiologists released consensus-based guidance recommending people who use GLP-1 receptor agonist drugs stop using them before surgery. Adults receiving daily GLP-1s were advised to stop the day of surgery, and those using a weekly GLP-1 were asked to stop therapy 7 days before surgery. However, David C. Klonoff, MD, FACP, FRCP (Edin), Fellow AIMBE, medical director of the Dorothy L. and James E. Frank Diabetes Research Institute of Mills-Peninsula Medical Center, noted that the guidance was based only on case reports and expert opinion. Klonoff and colleagues sought to conduct a retrospective cohort study to better assess surgical complication risks associated with diabetes medications.

“We know that when someone is taken off of diabetes medicine for surgery, they tend to have high blood sugar, and high blood sugar is associated with complications,” Klonoff told Healio. “Even as the anesthesiologists were embracing what they believed would be fewer perioperative and postoperative complications, they were also selecting a pathway that would lead to higher blood glucose levels at the time of surgery… Continue reading.

Redesigning diabetes technology to detect low blood sugar in older adults with diabetes and Alzheimer’s disease

Via Science Daily | December 6, 2022

Regenstrief Institute Research Scientist April Savoy, PhD, a human factors engineer and health services researcher, is developing and testing user-friendly health information tools and technology designed to enhance accessibility and value to older adults with both diabetes and Alzheimer’s disease, and their caregivers. Without numerous finger sticks, these tools and technology will be designed to provide patients, caregivers, and clinicians with glucose metrics needed to diagnose hypoglycemia and identify treatment options.

Older adults with Alzheimer’s and Type 1 or Type 2 diabetes have a high risk of low blood sugar, known as hypoglycemia, which is often undetected. Hypoglycemia can cause dizziness, confusion, mood changes, hospitalization, and even death. Diagnosis and treatment of hypoglycemia can prevent complications… Continue reading.