Northwestern investigators have identified a novel approach to control the hierarchical assembly of protein pathways with DNA, according to a study published the Proceedings of the National Academy of Sciences (PNAS).
The approach may facilitate the construction of synthetic protein materials, which can be used for a variety of medical and scientific purposes.
“Hierarchical assembly methods are transformative because the structure of the final material is dictated by the information programmed into each individual building block,” said Chad Mirkin, Ph.D., professor of Medicine in the Division of Hematology and Oncology, the George B. Rathmann Professor of Chemistry at Northwestern’s Weinberg College of Arts and Sciences, and lead author of the study… Continue reading.
A new immunotherapy developed by researchers at Northwestern University dramatically extends the survival time of mice with triple-negative breast cancer, one of the most aggressive and difficult-to-treat forms of breast cancer.
In a new study, mice treated with the therapy, which comprises two immunity-boosting drugs housed inside a nanoparticle, experienced complete tumor remission for at least 100 days. All untreated mice died by day 30. None of the treated mice experienced adverse side effects or autoimmune responses.
The nanoparticle, called a spherical nucleic acid (SNA), is a globular form of DNA that can easily enter and stimulate immune cells. Northwestern’s Chad A. Mirkin, who led the study and invented SNAs, credits the nanoparticle’s shape and structure for the immunotherapy’s success… Continue reading.
Researchers hope to make a dent in hospitals’ need with a single 3D printer
Northwestern University researchers have demonstrated the ability to generate 1,000 components for face shields per day — with a single 3D printer.
A critical piece of personal protective equipment (PPE), face shields protect health care workers from the novel coronavirus (COVID-19) as they treat patients.
When Northwestern researchers Chad A. Mirkin and David Walker heard about the PPE shortage in hospitals, their team sprang into action. In October, Mirkin and his research group, in a breakthrough article in the journal Science, unveiled a new 3D printing technique called “high-area rapid printing” (HARP), a 13-feet-tall printer with a 2.5 square-foot print bed that can print about half a yard in an hour — a record throughput for the 3D printing field… Continue reading.
Northwestern University’s Chad A. Mirkin, a world-renowned chemist and nanoscience expert, will receive the 2019 Perkin Medal from The Society of Chemical Industry (SCI), America Group. The award is widely considered as “the highest honor in American industrial chemistry.”
Mirkin is the George B. Rathmann Professor of Chemistry in the Weinberg College of Arts & Sciences and the director of the International Institute for Nanotechnology (IIN) at Northwestern. He also is a professor of chemical and biological engineering, biomedical engineering, and materials science and engineering in the McCormick School of Engineering and a professor of medicine at the Feinberg School of Medicine.
The 2019 Perkin Medal recognizes Mirkin’s contributions to nanotechnology and nanochemistry, and the many diagnostic, therapeutic, and materials applications that have derived from his discoveries, including the invention and development of spherical nucleic acids (SNAs) and numerous nanopatterning methodologies… Continue reading.
Different eras of civilization are defined by the discovery of new materials, as new materials drive new capabilities. And yet, identifying the best material for a given application — catalysts, light-harvesting structures, biodiagnostic labels, pharmaceuticals, and electronic devices—is traditionally a slow and daunting task. The options are nearly infinite, particularly at the nanoscale where material properties — optical, structural, electrical, mechanical, and chemical — can significantly change, even at a fixed composition.
A study published this week in the Proceedings of the National Academy of Sciences (PNAS) supports the efficacy of a potentially revolutionary new tool developed at Northwestern University to rapidly test millions — even billions — of nanoparticles to determine the best for a specific use.
“When utilizing traditional methods to identify new materials, we have barely scratched the surface of what is possible,” said Northwestern scientist Chad A. Mirkin, the study’s corresponding author and a world leader in nanotechnology research and its applications. “This research provides proof-of-concept — that this powerful approach to discovery science works… Continue reading.
Northwestern University’s Chad A. Mirkin and Chinese Academy of Sciences Professor Lei Jiang have been named recipients of the prestigious 2018 Nano Research Award.
Mirkin is the George B. Rathmann Professor of Chemistry in the Weinberg College of Arts and Sciences and director of the International Institute for Nanotechnology (IIN) at Northwestern. He is being honored for his achievements in nanoscience and nanotechnology, including his invention of dip-pen nanolithography, a suite of cantilever-free scanning probe lithography tools and spherical nucleic acids (SNAs) used in materials and colloidal crystal engineering, extracellular and intracellular molecular diagnostics, gene regulation and immune modulation therapies. SNAs are the basis for more than 1,600 commercial products, including four drugs undergoing human clinical trials… Continue reading.
Northwestern University’s Chad A. Mirkin will receive the prestigious Remsen Memorial Lecture Award for his outstanding discoveries in chemistry. The award is presented annually by the American Chemical Society Maryland Section, in conjunction with the Johns Hopkins department of chemistry.
Mirkin is the George B. Rathmann Professor of Chemistry and director of the International Institute for Nanotechnology at Northwestern.
The Remsen Award was created in 1946 in honor of Ira Remsen, the first chairman of the chemistry department and the second president at Johns Hopkins University. The honor recognizes chemists of outstanding achievements, mirroring Remsen’s long career as a professor and researcher. Remsen awardees include scientists Edward Teller, Willard Libby, R.B. Woodward, Charles Townes, Roald Hoffman and Robert Grubbs. To date, 17 Nobel laureates have received Remsen Awards… Continue reading.
In a rare honor for an American university, three Northwestern University scientists — Sir Fraser Stoddart, Chad Mirkin and Yonggang Huang — have been elected foreign members of the Chinese Academy of Sciences. The three were selected for their scientific achievements and contributions to promoting the development of science and technology in China.
Election to the academy is one of the highest honors that China bestows on a citizen of a foreign country. The Chinese Academy of Sciences elects new academicians and foreign members biennially. This year, the academy selected 16 foreign scientists from eight countries, including the three from Northwestern.
“To be recognized by the Chinese Academy as a foreign member is a wonderful honor that reflects the global impact our research in chemistry and nanoscience is having,” said Mirkin, director of the International Institute for Nanotechnology and the George B. Rathmann Professor of Chemistry… Continue reading.
Northwestern University’s Chad A. Mirkin received a prestigious 2017 Wilhelm Exner Medal at an award ceremony at the Hofburg Palace in Vienna on Oct. 19. He and CERN Director-General and particle physicist Fabiola Gianotti were each recognized with a medal at the ceremony.
The award is in recognition of Mirkin’s invention of spherical nucleic acids (SNAs), which are used in materials engineering, extracellular and intracellular molecular diagnostics, gene regulation and immune modulation. They form the basis for more than 1,600 commercial products, including three drugs that are in human clinical trials.
Mirkin joins an illustrious list of laureates that includes 21 Nobel Prize winners and scientific luminaries, such as Lord Ernest Rutherford, known as the father of nuclear physics; Charles H. Townes, inventor of the laser; and Stefan Hell, a 2016 Nobel laureate who pioneered super-resolved fluorescence microscopy. The medal has been awarded since 1921 by the Austrian Industry Association, Österreichischer Gewerbeverein (ÖGV) to scientists and inventors whose work has opened new possibilities in industrial applications.
“Any time one’s work is recognized with one of another country’s highest scientific honors, it is an extraordinary acknowledgment and validation of a life’s pursuit,” Mirkin said. He is the George B. Rathmann Professor of Chemistry and director of the International Institute for Nanotechnology at Northwestern… Continue reading.
WASHINGTON, D.C.— The American Institute for Medical and Biological Engineering (AIMBE) has announced the pending induction of Chad A. Mirkin, Ph.D., Director, International Institute for Nanotechnology; George B. Rathmann Professor of Chemistry, Professor of Medicine, Professor of Materials Science, Chemistry, Medicine, Materials Science, Northwestern University, to its College of Fellows. Dr. Mirkin was nominated, reviewed, and elected by peers and members of the College of Fellows For outstanding contribution to nanomaterials engineering, development and application widely used both academically and commercially as diagnostic and therapeutic agents.