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Samuel Stupp, Ph.D.

AIMBE College of Fellows Class of 2016
For the development of bioactive and self-assembling supramolecular biomaterials for regenerative medicine

Sam Stupp elected to the National Academy of Sciences

Via Northwestern University | April 28, 2020

Three Northwestern University faculty members — mathematician Laura DeMarco, engineer Yonggang Huang and materials scientist Samuel Stupp — have been elected to the prestigious National Academy of Sciences. Membership in the academy is one of the highest honors given to a scientist in the United States.

DeMarco, Huang and Stupp are among 120 new members and 26 new international members elected this year in recognition of distinguished and continuing achievements in original research. They will be inducted at the academy’s annual meeting next year.

Samuel Stupp

Stupp is Board of Trustees Professor of Materials Science and Engineering, Chemistry, Medicine, and Biomedical Engineering in McCormick and Weinberg College.

Stupp’s work integrates chemistry with materials science, biology and medicine. The overarching interest of his research group is the development of self-assembling organic materials, focusing on functions relevant to energy and medicine. One of his landmark achievements was the development of bioactive materials that can signal cells and be used in novel therapies for regenerative medicine.

He is a member of the National Academy of Engineering, the American Academy of Arts and Sciences, the Spanish Royal Academy, and the National Academy of Inventors, and a fellow of the American Physical Society, the Materials Research Society, and the Royal Society of Chemistry.

Stupp directs the Simpson Querrey Institute and its two affiliated research centers, the Center for Bio-Inspired Energy Science and the Center for Regenerative Nanomedicine… Continue reading.

Peptide Therapies Could Disable Coronavirus’ Spike Proteins

Via Northwestern University | April 13, 2020

Nanostructures could safely deliver a notoriously fragile drug to virus

Researchers are developing new peptide-based therapeutics for targeting and disabling the coronavirus’ so-called “spike proteins.”

Spike proteins — the crown of bulbous projections that give the coronavirus its signature halo effect — attach to and infect healthy cells, causing COVID-19. Led by Northwestern University and Massachusetts Institute of Technology (MIT), the research team is engineering a new nanostructured therapy that could potentially disable the virus and prevent its infection of human cells.

The idea is based on a recent discovery from the laboratory of Bradley L. Pentelute, an associate professor of chemistry at MIT. Pentelute’s team discovered a peptide molecule that specifically and strongly binds to the coronavirus’ spike protein… Continue reading.

New Technology to Manipulate Cells Could One Day Help Treat Parkinson’s, Arthritis, Other Diseases

Via Northwestern University | July 10, 2017

DNA strands in materials act like traffic signals to start, stop cell activity or regenerate tissue

A groundbreaking advancement in materials from Northwestern University could potentially help patients requiring stem cell therapies for spinal cord injuries, stroke, Parkinson’s disease, Alzheimer’s disease, arthritic joints or any other condition requiring tissue regeneration, according to a new study.

“It’s important in the context of cell therapies for people to cure these diseases or regenerate tissues that are no longer functional,” said senior author Samuel I. Stupp, director of Northwestern’s Simpson Querrey Institute for BioNanotechnology and Board of Trustees Professor of Materials Science and Engineering, Chemistry, Medicine and Biomedical Engineering.

The study was published today, July 10, in Nature Communications.

Cells in our bodies are constantly being signaled with many types of instructions coming from proteins and other molecules present in the matrices that surround them. For example, these can be cues for cells to express specific genes so they can proliferate or differentiate into several types of cells leading to growth or regeneration of tissues. One of the marvels of this signaling machinery is the built-in capacity in living organisms to make signals stop and re-start as needed, or to switch off one signal and activate a different one to orchestrate very complex processes. Building artificial materials with this type of dynamic capacity for regenerative therapies has been virtually impossible so far.

The new work published today reports the development of the first synthetic material that has the capability to trigger reversibly this type of dynamic signaling. The platform could not only lead to materials that manage stem cells for more effective regenerative therapies, but will also allow scientists to explore and discover in the laboratory new ways to control the fate of cells and their functions… Continue reading.

Samuel Stupp, Ph.D. To be Inducted into Medical and Biological Engineering Elite

Via AIMBE | January 20, 2016

WASHINGTON, D.C.— The American Institute for Medical and Biological Engineering (AIMBE) has announced the pending induction of Samuel Stupp, Ph.D., Board of Trustees Professor of Materials Science and Engineering, Chemistry, Medicine, and Biomedical Engineering, Director Simpson Querrey Institute, Director Center for Bio-inspired Energy Science, Materials Science and Engineering, Chemistry, Medicine, and Biomedical Engineering, Northwestern University, to its College of Fellows. Dr. Stupp was nominated, reviewed, and elected by peers and members of the College of Fellows For the development of bioactive and self-assembling supramolecular biomaterials for regenerative medicine.