A long-ignored white blood cell may be central to the immune system overreaction that is the most common cause of death for COVID-19 patients—and University of Michigan researchers found that rod-shaped particles can take them out of circulation.
The No. 1 cause of death for COVID-19 patients echoes the way the 1918 influenza pandemic killed: their lungs fill with fluid and they essentially drown. This is called acute respiratory distress syndrome. But a new way of drawing immune cells out of the lungs might be able to prevent this outcome. This research is among the essential projects at U-M that have continued through the pandemic uninterrupted… Continue reading.
A surprise finding suggests that an injection of nanoparticles may be able to help fight the immune system when it goes haywire, researchers at the University of Michigan have shown. The nanoparticles divert immune cells that cause inflammation away from an injury site.
Inflammation is a double-edged sword. When it works, it helps the body heal and fights off infections. But sometimes, the immune system overreacts. An acute lung injury, sustained by inhaling smoke, for instance, can lead to runaway fluid production that essentially drowns a person.
Now, experiments in mice suggest that simple plastic nanoparticles, delivered by IV, may be able to keep a type of immune cell—called a neutrophil—too busy to cause inflammation. Other diseases in which neutrophils cause excessive inflammation include sepsis and the hardening of the arteries, or atherosclerosis.
“Neutrophils are the first line of defense. They are the most active and the most optimized to mount an inflammatory response,” said Omolola Eniola-Adefeso, a professor of chemical engineering and biomedical engineering at U-M, who led the research… Continue reading.
WASHINGTON, D.C.— The American Institute for Medical and Biological Engineering (AIMBE) has announced the pending induction of Omolola Eniola-Adefeso, Ph.D., Associate Professor, Chemical Engineering, University of Michigan Ann Arbor, to its College of Fellows. Dr. Eniola-Adefeso was nominated, reviewed, and elected by peers and members of the College of Fellows For outstanding contributions to the understanding of particle transport in blood flow and the field of vascular-targeted drug delivery..