Researchers at Washington University in St. Louis have developed a new computational approach to removing movement in images of expanding and contracting heart cells and tissues. By computationally removing movement, the algorithm mimics a drug’s action in stopping the heart, without compromising cellular structure or tissue contractility.
Results of the research, led by Nathaniel Huebsch, an assistant professor of biomedical engineering, and Guy Genin, the Harold and Kathleen Faught Professor of Mechanical Engineering, both at the McKelvey School of Engineering, are published in the Sept. 11 Proceedings of the National Academy of Sciences… Continue reading.
When Srikanth Singamaneni and Guy Genin, both professors of mechanical engineering and materials science at the McKelvey School of Engineering at Washington University in St. Louis, established a new collaboration with researchers from the School of Medicine in late 2019, they didn’t know the landscape of infectious disease research was about to shift dramatically. In a conference room overlooking Forest Park on a beautiful fall day, the team had one goal in mind: tackle the biggest infectious disease problem facing the world right then.
“Srikanth and I had a vision of a simple, quantitative diagnostic tool, so we connected with infectious disease physicians here at WashU and asked them, ‘What are the most important questions that could be answered if you could get really detailed information cheaply at the point of care?’” said Genin, the Harold and Kathleen Faught Professor of Mechanical Engineering. “Greg Storch told us that one of the most important challenges facing the field of infectious disease is finding a way to figure out quickly if a patient has a bacterial infection and should get antibiotics or has a viral infection, for which antibiotics will not be effective… Continue reading.
Chronic kidney disease and eventual kidney failure are incurable diseases that affect 13% of the U.S. population, particularly those with high blood pressure and diabetes. These diseases degrade the “podocyte” cells of the kidney that maintain the body’s blood filtration system, eventually sending patients to dialysis.
The search for effective treatments has been hampered because these highly structured cells cannot be cultured outside of the body and because immortalized cell lines are not true to their structure. New research from Washington University’s McKelvey School of Engineering and the School of Medicine aims to overcome this critical barrier… Continue reading.
WASHINGTON, D.C.— The American Institute for Medical and Biological Engineering (AIMBE) has announced the pending induction of Guy M. Genin, Ph.D., Faculty Fellow of NSF Center for Engineering MechanoBiology, and Harold and Kathleen Faught Professor of Mechanical Engineering at Washington University in St. Louis, to its College of Fellows. Dr. Genin was nominated, reviewed, and elected by peers and members of the College of Fellows for outstanding contributions to the understanding of treatment of pathologies of interfaces, and leadership in biomechanics and mechano-biology.