Lintao Cai, Ph.D.

Researchers led by Prof. Cai Lintao from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences proposed a novel virus labeling strategy based on protein biosynthesis for dynamic visualization of nonenveloped enterovirus 71 infection. The study was published in ACS Applied Materials & Interfaces.

Enterovirus 71 (EV71), a major cause of severe hand-foot-and-mouth disease (HFMD), can develop into serious and life-threatening neurological complications, such as brainstem encephalitis, meningitis, and poliomyelitis-like paralysis. Understanding the viral invasion pathway of EV71 is important for elucidating its pathogenesis… Continue reading.

Engineered T cell immunotherapy, such as chimeric antigen receptor T cell (CAR-T) and T cell receptor T cell (TCR-T) therapy, has emerged as a potent therapeutic strategy for treating tumors.

However, the genetic manipulation of primary T cells remains inefficient, especially during the clinical manufacturing process. There’s an urgent need to develop a reliable method for the preparation of engineered T cells.

A research team, led by Prof. CAI Lintao at the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, and other collaborators developed a “safe, efficient and universal” technique based on bioorthogonal chemistry and glycol-metabolic labeling for viral-mediated engineered T cell manufacturing. Their findings were published in Advanced Functional Materials… Continue reading.

WASHINGTON, D.C.—The American Institute for Medical and Biological Engineering (AIMBE) has announced the induction of Lintao Cai, Ph.D., Director, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, to its College of Fellows.

Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to a medical and biological engineer. The College of Fellows is comprised of the top two percent of medical and biological engineers. College membership honors those who have made outstanding contributions to “engineering and medicine research, practice, or education” and to “the pioneering of new and developing fields of technology, making major advancements in traditional fields of medical and biological engineering, or developing/implementing innovative approaches to bioengineering education.”

Dr. Cai was nominated, reviewed, and elected by peers and members of the College of Fellows for “outstanding contributions to optical imaging probes and biomimetic drug delivery systems in the fields of nanomedicine and cancer theranostics.”