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Zhen Gu, Ph.D.

AIMBE College of Fellows Class of 2019
For outstanding contributions to advancing fundamental and technological innovations in the field of drug delivery.

Artificial beta cells could lead to new diabetes treatment

Via Open Access Government | June 25, 2020

The artificial beta cells (ABCs) are much more patient-friendly and mimic the functions of the body’s natural glucose-controllers. The idea is that the AβCs could be subcutaneously inserted into patients, which would be replaced every few days, or by a painless and disposable skin patch.

The ABCs are constructed with a simplified version of a normal cell’s two-layered lipid membrane. The key innovation is what these cells contain: specially designed, insulin-stuffed vesicles. A rise in blood glucose levels leads to chemical changes in the vesicle coating, causing the vesicles to start fusing with the ABC’s outer membrane – thus releasing the insulin payloads… Continue reading.

Coin-sized smart insulin patch, potential diabetes treatment

Via Science Daily | February 4, 2020

UCLA bioengineers and colleagues at UNC School of Medicine and MIT have further developed a smart insulin-delivery patch that could one day monitor and manage glucose levels in people with diabetes and deliver the necessary insulin dosage. The adhesive patch, about the size of a quarter, is simple to manufacture and intended for once-a-day use.

The study, published in Nature Biomedical Engineering, describes research conducted on mice and pigs. The research team, led by Zhen Gu, PhD, professor of bioengineering at the UCLA Samueli School of Engineering, is applying for FDA approval of clinical trials in humans. Gu and colleagues conducted the initial successful tests of the smart insulin patch in mice in 2015 in North Carolina… Continue reading.

‘Smart’ insulin could reduce dangerous complications of diabetes treatment

Via The North Carolina Translational and Clinical Sciences | May 14, 2019

A study supported by the North Carolina Translational and Clinical Sciences (NC TraCS) Institute has developed a “smart” insulin that could reduce dangerous complications in people who use the drug to manage diabetes. This new type of insulin, called i-insulin, is released for action when the blood sugar or glucose levels rise and blocks its own activity when glucose levels fall.

The findings, generated in mice, appeared this week in the Proceedings of the National Academy of Sciences. The research was led by former University of North Carolina at Chapel Hill researcher Zhen Gu, PhD, now a professor of bioengineering at UCLA… Continue reading.

Dr. Zhen Gu Inducted into Medical and Biological Engineering Elite

Via AIMBE | March 28, 2019

WASHINGTON, D.C.—The American Institute for Medical and Biological Engineering (AIMBE) has announced the induction of Zhen Gu, Ph.D., Professor, Department of Bioengineering, University of California, Los Angeles, to its College of Fellows.

Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to a medical and biological engineer. The College of Fellows is comprised of the top two percent of medical and biological engineers. College membership honors those who have made outstanding contributions to “engineering and medicine research, practice, or education” and to “the pioneering of new and developing fields of technology, making major advancements in traditional fields of medical and biological engineering, or developing/implementing innovative approaches to bioengineering education.”

Dr. Gu was nominated, reviewed, and elected by peers and members of the College of Fellows for “outstanding contributions to advancing fundamental and technological innovations in the field of drug delivery.”