Anne E. Carpenter, Ph.D.

An international team led by researchers at the University of Toronto and the Broad Institute of MIT and Harvard has assembled the first large-scale, publicly available map to show the impact of mutations on where proteins end up in the cell.

The team developed a high-throughput imaging platform to assess the influence of nearly 3,500 mutations on protein location. They found that roughly one in six disease-causing mutations led to proteins ending up in the wrong location in the cell.

“Technological advances in genetic sequencing have allowed researchers to identify thousands of protein mutations that cause disease… Continue reading.

Scientists have learned a lot about human biology by looking at cells under a microscope, but they might not notice tiny differences between cells or even know what they’re looking for. Researchers at the Broad Institute of MIT and Harvard, in the laboratories of Anne Carpenter and Stuart Schreiber, first started developing cell painting 13 years ago to take cell imaging to the next level. The method, further advanced by Carpenter, now senior director of the Broad’s Imaging Platform and senior group leader Shantanu Singh, and colleagues, uses six colored dyes to stain eight different cell organelles. Machine learning models recognize subtle differences in the images—changes in cell morphology that might indicate disease or a drug or genetic perturbation—which allows researchers to predict the effects of a drug or mutation.

The Broad team has recently made strides in scaling up the method. They have spent the last several years building a consortium of drugmakers and academic institutions to create the world’s largest public cell painting database, which drug developers hope will help accelerate their search for promising drug candidates… Continue reading.

WASHINGTON, D.C. — The American Institute for Medical and Biological Engineering (AIMBE) has announced the induction of Anne E. Carpenter, Ph.D., Institute Scientist and Senior Director of the Imaging Platform, Broad Institute of Harvard and MIT, to its College of Fellows.

Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to a medical and biological engineer. The College of Fellows is comprised of the top two percent of medical and biological engineers. College membership honors those who have made outstanding contributions to “engineering and medicine research, practice, or education” and to “the pioneering of new and developing fields of technology, making major advancements in traditional fields of medical and biological engineering, or developing/implementing innovative approaches to bioengineering education.”

Dr. Carpenter was nominated, reviewed, and elected by peers and members of the College of Fellows for “pioneering contributions to image-based cell profiling, bridging the gap between image computing and biology.“