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Qiaobing Xu, Ph.D.

AIMBE College of Fellows Class of 2020
For outstanding contributions to develop synthetic lipid nanoparticles for intracellular protein delivery for therapeutics including cancer therapy and gene editing.

Drug Delivery Nanoparticles Given Neurotransmitter “Passports” to Cross Blood-Brain Barrier

Via Genetic Engineering & Biotechnology News | July 27, 2020

Biomedical engineers at Tufts University School of Engineering have developed tiny lipid-based nanoparticles that incorporate neurotransmitters, which can help to carry drugs, large molecules, and even gene editing proteins across the blood-brain barrier (BBB) and into the brain in mice. The researchers believe the new neurotransmitter-derived lipidoids—or NT-lipidoids—could overcome many of the current limitations encountered in delivering intravenously administered therapeutics into the central nervous system (CNS), and open up the potential to use a range of therapeutics that would otherwise not have access to the brain.

“The power of our method is that it is extremely versatile and relatively non-disruptive,” said Qiaobing Xu, PhD, associate professor of biomedical engineering at Tufts University and corresponding author of the team’s published paper in Science Advances. “We can deliver a wide range of molecules by packaging them into the lipid-based nanoparticles without chemically modifying the drugs themselves. We can also achieve delivery across the blood-brain barrier without disrupting the integrity of the barrier.” Xu and colleagues described the technology in a paper titled, “Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection… Continue reading.

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Dr. Qiaobing Xu Inducted into AIMBE College of Fellows

Via AIMBE | March 30, 2020

WASHINGTON, D.C. — The American Institute for Medical and Biological Engineering (AIMBE) has announced the induction of Qiaobing Xu, Ph.D., Associate Professor, Biomedical engineering, Tufts University, to its College of Fellows.

Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to a medical and biological engineer. The College of Fellows is comprised of the top two percent of medical and biological engineers. College membership honors those who have made outstanding contributions to “engineering and medicine research, practice, or education” and to “the pioneering of new and developing fields of technology, making major advancements in traditional fields of medical and biological engineering, or developing/implementing innovative approaches to bioengineering education.”

Dr. Xu was nominated, reviewed, and elected by peers and members of the College of Fellows for “outstanding contributions to develop synthetic lipid nanoparticles for intracellular protein delivery for therapeutics including cancer therapy and gene editing.

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