Toll-like receptor (TLR) and saponin adjuvants have each improved vaccine potency and safety. Now, researchers at Stanford University report that combining them in a nanoparticle format improves not only potency, but also durability, target breadth, and degree of virus neutralization.
A modular approach makes it possible to fine-tune adjuvants by mixing and matching saponin nanoparticles (SNPs) and TLR adjuvants in the same nanostructure to elicit tailored immune responses, according to a recent paper by Eric Appel, PhD, associate professor of materials science and engineering at Stanford University, senior author, and Ben Ou, first author and a doctoral student in the Appel Lab… Continue reading.
...WASHINGTON, D.C.— The American Institute for Medical and Biological Engineering (AIMBE) has announced the induction of Eric A. Appel, Ph.D., Associate Professor at Stanford University to its College of Fellows.
Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to medical and biological engineers, comprised of the top two percent of engineers in these fields. College membership honors those who have made outstanding contributions to “engineering and medicine research, practice, or education” and to “the pioneering of new and developing fields of technology, making major advancements in traditional fields of medical and biological engineering or developing/implementing innovative approaches to bioengineering education.”
Professor Appel was nominated, reviewed, and elected by peers and members of the College of Fellows “for pioneering contributions to advance the application of supramolecular chemistry to prepare functional biomaterials and drug delivery technologies…. Continue reading.
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