Shana O. Kelley, Ph.D.

AIMBE College of Fellows Class of 2016
For outstanding contributions to the development of new chip-based sensors for point-of-care molecular analysis

New DNA Identification Approach Could Improve Monitoring for Chronic Diseases

Via Northwestern University | July 26, 2023

Investigators led by Shana Kelley, PhD, the Neena B. Schwartz Professor of Chemistry, Biomedical Engineering, and of Biochemistry and Molecular Genetics, have developed a novel approach for identifying sequences of artificial DNA with differing levels of binding to other small molecules.

The approach, detailed in a study published in Nature Chemistry, could help improve the efficiency of diagnostic monitoring for patients with chronic diseases.

Aptamers are sequences of artificial DNA that selectively bind to other small molecules such as peptides, carbohydrates and foreign pathogens. Aptamers can be used for therapeutic purposes in the same way as monoclonal antibodies, and have been used for pathogen and cancer recognition as well as stem cell markers… Continue reading.

Gene Loss Enhances Metastasis and Cancer Progression

Via Northwestern University | September 29, 2022

Investigators have discovered that the loss of the gene SLIT2 in circulating tumor cells regulates metastasis of prostate cancer tumors, according to a Northwestern Medicine study published in Science Advances.

Metastasis accounts for most cancer-related deaths, yet its underlying mechanisms have remained poorly understood despite recent advances in cancer treatments and care… Continue reading.

New tool harnesses immune cells from tumors to effectively fight cancer

Via News-Medical.Net | January 28, 2022

Northwestern scientists have developed a new tool to harness immune cells from tumors to fight cancer rapidly and effectively, published in the journal Nature Biomedical Engineering.

Their findings showed a dramatic shrinkage in tumors in mice compared to traditional cell therapy methods. With a novel microfluidic device that could be 3D printed, the team multiplied, sorted through and harvested hundreds of millions of cells, recovering 400 percent more of the tumor-eating cells than current approaches… Continue reading.

Shana O. Kelley, Ph.D. To be Inducted into Medical and Biological Engineering Elite

Via AIMBE | January 20, 2016

WASHINGTON, D.C.— The American Institute for Medical and Biological Engineering (AIMBE) has announced the pending induction of Shana O. Kelley, Ph.D., Distinguished Professor, undefined, University of Toronto, to its College of Fellows. Dr. Kelley was nominated, reviewed, and elected by peers and members of the College of Fellows For outstanding contributions to the development of new chip-based sensors for point-of-care molecular analysis.