Omolola Eniola-Adefeso, Ph.D.

AIMBE College of Fellows Class of 2017
For outstanding contributions to the understanding of particle transport in blood flow and the field of vascular-targeted drug delivery.

Director Lander, the time is now

Via AAAS | July 2, 2021

The Biden administration’s decision to elevate the Director of the White House Office of Science and Technology Policy (OSTP) to a cabinet-level position is a win for science. Eric Lander, confirmed in May by the Senate, is now advising the president on the scientific, engineering, and technological policies of the US government. As Dr. Lander carries out this task, we hope that he keeps in mind what President Biden asked him in a letter in January: “How can we guarantee that the fruits of science and technology are fully shared across America and among all Americans?”

The challenges ahead are formidable. The devastating health and economic impacts of two major crises—climate change and the COVID-19 pandemic—have revealed deep societal fault lines that prevent the United States from drawing on the talents of all Americans to tackle these problems. Thus, there is an urgent need for smart and socially minded policy-making… Continue reading.

How rod-shaped particles might distract an out-of-control COVID immune response

Via University of Michigan | June 10, 2020

A long-ignored white blood cell may be central to the immune system overreaction that is the most common cause of death for COVID-19 patients—and University of Michigan researchers found that rod-shaped particles can take them out of circulation.

The No. 1 cause of death for COVID-19 patients echoes the way the 1918 influenza pandemic killed: their lungs fill with fluid and they essentially drown. This is called acute respiratory distress syndrome. But a new way of drawing immune cells out of the lungs might be able to prevent this outcome. This research is among the essential projects at U-M that have continued through the pandemic uninterrupted… Continue reading.

Nanoparticles can limit inflammation by distracting the immune system

Via | November 8, 2017

A surprise finding suggests that an injection of nanoparticles may be able to help fight the immune system when it goes haywire, researchers at the University of Michigan have shown. The nanoparticles divert immune cells that cause inflammation away from an injury site.

Inflammation is a double-edged sword. When it works, it helps the body heal and fights off infections. But sometimes, the immune system overreacts. An acute lung injury, sustained by inhaling smoke, for instance, can lead to runaway fluid production that essentially drowns a person.

Now, experiments in mice suggest that simple plastic nanoparticles, delivered by IV, may be able to keep a type of immune cell—called a neutrophil—too busy to cause inflammation. Other diseases in which neutrophils cause excessive inflammation include sepsis and the hardening of the arteries, or atherosclerosis.

“Neutrophils are the first line of defense. They are the most active and the most optimized to mount an inflammatory response,” said Omolola Eniola-Adefeso, a professor of chemical engineering and biomedical engineering at U-M, who led the research… Continue reading.

Omolola Eniola-Adefeso, Ph.D. To be Inducted into Medical and Biological Engineering Elite

Via AIMBE | March 7, 2017

WASHINGTON, D.C.— The American Institute for Medical and Biological Engineering (AIMBE) has announced the pending induction of Omolola Eniola-Adefeso, Ph.D., Associate Professor, Chemical Engineering, University of Michigan Ann Arbor, to its College of Fellows. Dr. Eniola-Adefeso was nominated, reviewed, and elected by peers and members of the College of Fellows For outstanding contributions to the understanding of particle transport in blood flow and the field of vascular-targeted drug delivery..