Engineered T cell immunotherapy, such as chimeric antigen receptor T cell (CAR-T) and T cell receptor T cell (TCR-T) therapy, has emerged as a potent therapeutic strategy for treating tumors.

However, the genetic manipulation of primary T cells remains inefficient, especially during the clinical manufacturing process. There’s an urgent need to develop a reliable method for the preparation of engineered T cells.

A research team, led by Prof. CAI Lintao at the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, and other collaborators developed a “safe, efficient and universal” technique based on bioorthogonal chemistry and glycol-metabolic labeling for viral-mediated engineered T cell manufacturing. Their findings were published in Advanced Functional Materials… Continue reading.