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Writing the Book in DNA

George M. Church | Via Wyss Institute at Harvard | August 16, 2012

Although George Church’s next book doesn’t hit the shelves until Oct. 2, it has already passed an enviable benchmark: 70 billion copies — roughly triple the sum of the top 100 books of all time.

And they fit on your thumbnail.

That’s because Church, a founding core faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Robert Winthrop Professor of Genetics at Harvard Medical School, and his team encoded in DNA the book, Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves in DNA, which they then decoded and copied.

Biology’s databank, DNA has long tantalized researchers with its potential as a storage medium: fantastically dense, stable, energy-efficient and proven to work over a timespan of some 3.5 billion years. While not the first project to demonstrate the potential of DNA storage, Church’s team married next-generation sequencing technology with a novel strategy to encode 1,000 times the largest amount of data previously stored in DNA.

The team reports its results in the Aug. 17 issue of the journal Science

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